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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
08/03/2023 |
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Actualizado : |
15/03/2023 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
RAMOS, Z.; GARRICK , D. J.; BLAIR, H. T.; VERA, B.; CIAPPESONI, G.; KENYON, P. R. |
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Afiliación : |
ZULLY MARGOT RAMOS ALVEZ, School of Agriculture and Environment, Massey University, Palmerston North 4410, New Zealand; DORIAN J. GARRICK, School of Agriculture and Environment, Massey University, Palmerston North 4410, New Zealand; HUGH T. BLAIR, School of Agriculture and Environment, Massey University, Palmerston North 4410, New Zealand; BRENDA VERA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CARLOS GABRIEL CIAPPESONI SCARONE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; PAUL R. KENYON, School of Agriculture and Environment, Massey University, Palmerston North 4410, New Zealand. |
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Título : |
Genomic regions associated with wool, growth and reproduction traits in Uruguayan Merino Sheep. |
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Fecha de publicación : |
2023 |
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Fuente / Imprenta : |
Genes, 2023, volume 14, issue 1, article 167. OPEN ACCESS. doi: https://doi.org/10.3390/genes14010167 |
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ISSN : |
2073-4425 |
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DOI : |
10.3390/genes14010167 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 13 December 2022; Revised 29 December 2022; Accepted 4 January 2023; Published 7 January 2023. -- Correspondence author: Zully Ramos, email: z.ramosalvez@massey.ac.nz -- Academic Editor: Qiuyue Liu -- This article belongs to the Section Animal Genetics and Genomics (https://www.mdpi.com/journal/genes/sections/Animal_Genetics_Genomics ) -- FUNDING: his research was funded by the Regional Consortium for Innovation in Ultrafine Wool (CRILU), the European Union?s Horizon 2020 research and innovation program under the grant agreement n°772787 (Smarter) and the National Institute of Agricultural Research of Uruguay (INIA_CL_38: Rumiar). This study was supported by two Ph.D. scholarships (from the National Agency for Investigation and Innovation of Uruguay, ANII, and Massey University, New Zealand), awarded to Zully Ramos. -- LICENSSE: Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). --
Supplementary Materials The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/genes14010167/s1, Table S1: Enrichment analysis. |
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Contenido : |
The aim of this study was to identify genomic regions and genes associated with the fiber diameter (FD), clean fleece weight (CFW), live weight (LW), body condition score (BCS), pregnancy rate (PR) and lambing potential (LP) of Uruguayan Merino sheep. Phenotypic records of approximately 2000 mixed-age ewes were obtained from a Merino nucleus flock. Genome-wide association studies were performed utilizing single-step Bayesian analysis. For wool traits, a total of 35 genomic windows surpassed the significance threshold (PVE > 0.25%). The proportion of the total additive genetic variance explained by those windows was 4.85 and 9.06% for FD and CFW, respectively. There were 42 windows significantly associated with LWM, which collectively explained 43.2% of the additive genetic variance. For BCS, 22 relevant windows accounted for more than 40% of the additive genetic variance, whereas for the reproduction traits, 53 genomic windows (24 and 29 for PR and LP, respectively) reached the suggestive threshold of 0.25% of the PVE. Within the top 10 windows for each trait, we identified several genes showing potential associations with the wool (e.g., IGF-1, TGFB2R, PRKCA), live weight (e.g., CAST, LAP3, MED28, HERC6), body condition score (e.g., CDH10, TMC2, SIRPA, CPXM1) or reproduction traits (e.g., ADCY1, LEPR, GHR, LPAR2) of the mixed-age ewes. Copyright: © 2023 by the authors |
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Palabras claves : |
Body condition score; Fiber diameter; Gene; GWAS; Reproduction; Sheep. |
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Asunto categoría : |
L10 Genética y mejoramiento animal |
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URL : |
https://www.mdpi.com/2073-4425/14/1/167/pdf
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Marc : |
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022 $a2073-4425
024 7 $a10.3390/genes14010167$2DOI
100 1 $aRAMOS, Z.
245 $aGenomic regions associated with wool, growth and reproduction traits in Uruguayan Merino Sheep.$h[electronic resource]
260 $c2023
500 $aArticle history: Received 13 December 2022; Revised 29 December 2022; Accepted 4 January 2023; Published 7 January 2023. -- Correspondence author: Zully Ramos, email: z.ramosalvez@massey.ac.nz -- Academic Editor: Qiuyue Liu -- This article belongs to the Section Animal Genetics and Genomics (https://www.mdpi.com/journal/genes/sections/Animal_Genetics_Genomics ) -- FUNDING: his research was funded by the Regional Consortium for Innovation in Ultrafine Wool (CRILU), the European Union?s Horizon 2020 research and innovation program under the grant agreement n°772787 (Smarter) and the National Institute of Agricultural Research of Uruguay (INIA_CL_38: Rumiar). This study was supported by two Ph.D. scholarships (from the National Agency for Investigation and Innovation of Uruguay, ANII, and Massey University, New Zealand), awarded to Zully Ramos. -- LICENSSE: Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). -- Supplementary Materials The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/genes14010167/s1, Table S1: Enrichment analysis.
520 $aThe aim of this study was to identify genomic regions and genes associated with the fiber diameter (FD), clean fleece weight (CFW), live weight (LW), body condition score (BCS), pregnancy rate (PR) and lambing potential (LP) of Uruguayan Merino sheep. Phenotypic records of approximately 2000 mixed-age ewes were obtained from a Merino nucleus flock. Genome-wide association studies were performed utilizing single-step Bayesian analysis. For wool traits, a total of 35 genomic windows surpassed the significance threshold (PVE > 0.25%). The proportion of the total additive genetic variance explained by those windows was 4.85 and 9.06% for FD and CFW, respectively. There were 42 windows significantly associated with LWM, which collectively explained 43.2% of the additive genetic variance. For BCS, 22 relevant windows accounted for more than 40% of the additive genetic variance, whereas for the reproduction traits, 53 genomic windows (24 and 29 for PR and LP, respectively) reached the suggestive threshold of 0.25% of the PVE. Within the top 10 windows for each trait, we identified several genes showing potential associations with the wool (e.g., IGF-1, TGFB2R, PRKCA), live weight (e.g., CAST, LAP3, MED28, HERC6), body condition score (e.g., CDH10, TMC2, SIRPA, CPXM1) or reproduction traits (e.g., ADCY1, LEPR, GHR, LPAR2) of the mixed-age ewes. Copyright: © 2023 by the authors
653 $aBody condition score
653 $aFiber diameter
653 $aGene
653 $aGWAS
653 $aReproduction
653 $aSheep
700 1 $aGARRICK , D. J.
700 1 $aBLAIR, H. T.
700 1 $aVERA, B.
700 1 $aCIAPPESONI, G.
700 1 $aKENYON, P. R.
773 $tGenes, 2023, volume 14, issue 1, article 167. OPEN ACCESS. doi: https://doi.org/10.3390/genes14010167
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INIA Las Brujas (LB) |
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| Registros recuperados : 4 | |
| 2. |  | RAMOS, Z.; GARRICK , D. J.; BLAIR, H. T.; VERA, B.; CIAPPESONI, G.; KENYON, P. R. Genomic regions associated with wool, growth and reproduction traits in Uruguayan Merino Sheep. Genes, 2023, volume 14, issue 1, article 167. OPEN ACCESS. doi: https://doi.org/10.3390/genes14010167 Article history: Received 13 December 2022; Revised 29 December 2022; Accepted 4 January 2023; Published 7 January 2023. -- Correspondence author: Zully Ramos, email: z.ramosalvez@massey.ac.nz -- Academic Editor: Qiuyue Liu -- This...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 3. | | NAVAJAS, E.; GARRICK, D.J.; PLEASANTS, A.B.; MORRIS, C.A. Superiority of a biochemically-based approach for the detection of a quantitative trait locus affecting ultimate pH. Session 11. Growth and meat quality Communication No. 11-16. In: Proceedings of the World Congress on Genetics Applied to Livestock Production, 7., Montpellier, France, August 19-23, 2002, p. 11-16.| Tipo: Trabajos en Congresos/Conferencias |
| Biblioteca(s): INIA Las Brujas. |
|  |
| 4. | | RAMOS, Z.; GARRICK, D.J.; BLAIR, H.T.; DE BARBIERI, I.; CIAPPESONI, G.; MONTOSSI, F.; KENYON, P.R. Genetic and phenotypic relationships between ewe reproductive performance and wool and growth traits in Uruguayan Ultrafine Merino sheep. Journal of Animal Science, 2023, Volume 101, skad071. OPEN ACCESS. https://doi.org/10.1093/jas/skad071 Article history: Received 13 July 2022; Accepted 06 March 2023; Published 07 March 2023; Corrected and typeset 14 April 2023. -- Corresponding author: z.ramosalvez@massey.ac.nz -- Issue Section: Animal Genetics and Genomics...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| Registros recuperados : 4 | |
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